2H-Benzo[1,4]thiazin-3-one Derivatives Endowed with Antifungal Activity

Fernando Armini Ruela, Juliana Luisa Teixeira de Andrade, Nathalia Duarte de Sá, Elisabete Silva Barros, Vera Lucia de Miranda Guarda


The in vitro susceptibility tests with terbinafine and fluconazole, using the CLSI methodology were described to evaluate the 2H-benzo[1,4]thiazin-3-one derivatives. All compounds synthesized were investigated in vitro against Candida spp. Minimum inhibitory concentration (MIC) endpoints were read visually after 48 hours of incubation and the susceptibilities were measured.

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ISSN: 2447-8091